これまで、ヒト脂肪幹細胞培養上清液から凍結乾燥されたタンパク質製剤を活用した毛髪再生治療が行われてきましたが、最近の知見ではエクソソーム製剤による治療が注目され、その効果が期待されています。
掲載論文
- Park KY, Han HS, Park JW, Kwon HH, Park GH, Seo SJ. Exosomes derived from human adipose tissue-derived mesenchymal stem cells for the treatment of dupilumab-related facial redness in patients with atopic dermatitis: A report of two cases. J Cosmet Dermatol. 2022 Feb;21(2):844-849. doi: 10.1111/jocd.14153. Epub 2021 Apr 29. PMID: 33844417.
- Shin KO, Ha DH, Kim JO, Crumrine DA, Meyer JM, Wakefield JS, Lee Y, Kim B, Kim S, Kim HK, Lee J, Kwon HH, Park GH, Lee JH, Lim J, Park S, Elias PM, Park K, Yi YW, Cho BS. Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. Cells. 2020 Mar 10;9(3):680. doi: 10.3390/cells9030680. PMID: 32164386; PMCID: PMC7140723.
- Kwon HH, Yang SH, Lee J, Park BC, Park KY, Jung JY, Bae Y, Park GH. Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study. Acta Derm Venereol. 2020 Nov 4;100(18):adv00310. doi: 10.2340/00015555-3666. PMID: 33073298; PMCID: PMC9309822.
- Ha DH, Kim SD, Lee J, Kwon HH, Park GH, Yang SH, Jung JY, Lee JH, Park SR, Youn J, Lee SH, Kim JE, Lim J, Lee HK, Cho BS, Yi YW. Toxicological evaluation of exosomes derived from human adipose tissue-derived mesenchymal stem/stromal cells. Regul Toxicol Pharmacol. 2020 Aug;115:104686. doi: 10.1016/j.yrtph.2020.104686. Epub 2020 May 22. PMID: 32450131.
- Ha DH, Kim HK, Lee J, Kwon HH, Park GH, Yang SH, Jung JY, Choi H, Lee JH, Sung S, Yi YW, Cho BS. Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration. Cells. 2020 May 7;9(5):1157. doi: 10.3390/cells9051157. PMID: 32392899; PMCID: PMC7290908.
- Cho, Byong Seung and Lee, Jinah and Won, Yujin and Duncan, Diane I. and Jin, Richard C. and Lee, Joon and Kwon, Hyuck Hoon and Park, Gyeong-Hun and Yang, Steven Hoseong and Park, Byung Cheol and Park, Kui Young and Youn, Jinkwon and Chae, Junsoo and Jung, Minwoong and Yi, Yong Weon. Skin Brightening Efficacy of Exosomes Derived from Human Adipose Tissue-Derived Stem/Stromal Cells: A Prospective, Split-Face, Randomized Placebo-Controlled Study. Cosmetics, 7 (4). p. 90. ISSN 2079-9284
- Lee JH, Ha DH, Go HK, Youn J, Kim HK, Jin RC, Miller RB, Kim DH, Cho BS, Yi YW. Reproducible Large-Scale Isolation of Exosomes from Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Their Application in Acute Kidney Injury. Int J Mol Sci. 2020 Jul 5;21(13):4774. doi: 10.3390/ijms21134774. PMID: 32635660; PMCID: PMC7370182.
- Yi YW, Lee JH, Kim SY, Pack CG, Ha DH, Park SR, Youn J, Cho BS. Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging. Int J Mol Sci. 2020 Jan 19;21(2):665. doi: 10.3390/ijms21020665. PMID: 31963931; PMCID: PMC7014306.
- Park KY, Han HS, Park JW, Kwon HH, Park GH, Seo SJ. Exosomes derived from human adipose tissue-derived mesenchymal stem cells for the treatment of dupilumab-related facial redness in patients with atopic dermatitis: A report of two cases. J Cosmet Dermatol. 2022 Feb;21(2):844-849. doi: 10.1111/jocd.14153. Epub 2021 Apr 29. PMID: 33844417.
特許
- Patent for hair growth or preventing hair loss
Freeze-dried formulation of exosomes derived from stem cell and composition comprising the same for promoting hair growth or preventing hair loss - Patent for acne improvement
Freeze-dried formulation of exosomes derived from stem cell and composition for preventing, suppressing, alleviating, improving or treating acne comprising the same - Patent for acne improvement
Freeze-dried formulation of exosomes derived from stem cell and composition for preventing, suppressing, alleviating, improving or treating acne comprising the same - Patent for exosome productivity and bioactivity
Manufacturing method of exosome for enhancing its bioactivity and application thereof - Patent for ExoSCRTTM manufacturing process
(ExoSCRTTM) A method to isolate and purify an exosome and/or extracellular vesicle and a composition comprising it) - Patent for use of atopic dermatitis
(Atopic dermatitis) A composition comprising an exosome derived from adipose-derived stem cell as an active ingredient and its application for improving dermatitis - Patent for strengthening the skin barrier
(Skin barrier) A composition comprising an exosome and/or extracellular vesicle derived from stem cell as an active ingredient and its application for reinforcing or improving skin barrier - Patent for freeze drying exosome
(Freeze drying) Method for freeze-drying exosomes - Patent for freeze drying exosome
(Freeze drying) Method for freeze-drying exosomes - Patent for moisturizing skin and improving pruritus
(CelltweetTM) Cosmetic composition for moisturizing skin and improving pruritus - Exosomal filler patent
(Exosomal filler) Filler composition of stabilized exosome - Patent for relieving itching
(EXOMAGETM) New use of exosome kit comprising exosomes derived from stem cells - Patent for whitening and wrinkle reducing
(Exosome cosmetics) Cosmetic composition containing exosomes extracted from stem cell for skin whitening, antiwrinkle or regeneration - Patent application for exosome kit
New use of exosome kit comprising exosomes derived from stem cells - Patent application for exosome productivity and bioactivity
Manufacturing method of exosomes for increasing their productivity and bioactivity and its application - Patent for exosome and PDRN
New composition comprising exosomes derived from stem cell and polydeoxyribonucleotide - Patent for exosome and PDRN
New composition comprising exosomes derived from stem cell and polydeoxyribonucleotide - Patent for transdermal delivery of exosomes
Exosome kit and method for improving transdermal delivery of exosomes using the same - Patent application for improving dermatitis
A composition comprising an exosome derived from adipose-derived stem cell as an active ingredient and its application for improving dermatitis - Patent for exosomal membrane protein variant
Exosomes comprising exosomal membrane protein variant and manufacturing method thereof